Design and characterization of a constitutively open KcsA.
Cuello LG, Jogini V, Cortes DM, Sompornpisut A, Purdy MD, Wiener MC, Perozo E.
FEBS Lett. 2010 Feb 12. 
A molecular mechanism for proton-dependent gating in KcsA.
Cuello LG, Cortes DM, Jogini V, Sompornpisut A, Perozo E.
FEBS Lett. 2010 Feb 6.
A designer ligand specific for Kv1.3 channels from a scorpion neurotoxin-based library.
Takacs Z, Toups M, Kollewe A, Johnson E, Cuello LG, Driessens G, Biancalana M, Koide A, Ponte CG, Perozo E, Gajewski TF, Suarez-Kurtz G, Koide S, Goldstein SA.
Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22211-6. 
Structural dynamics of an isolated voltage-sensor domain in a lipid bilayer.
Chakrapani S, Cuello LG, Cortes DM, Perozo E.
Structure. 2008 Mar;16(3):398-409.

Detection of the opening of the bundle crossing in KcsA with fluorescence lifetime spectroscopy reveals the existence of two gates for ion conduction.
Blunck R, Cordero-Morales JF, Cuello LG, Perozo E, Bezanilla F.
J Gen Physiol. 2006 Nov;128(5):569-81. Epub 2006 Oct 16.

Molecular determinants of gating at the potassium-channel selectivity filter.
Cordero-Morales JF, Cuello LG, Zhao Y, Jogini V, Cortes DM, Roux B, Perozo E.
Nat Struct Mol Biol. 2006 Apr;13(4):311-8. Epub 2006 Mar 12.

Voltage-dependent gating at the KcsA selectivity filter.
Cordero-Morales JF, Cuello LG, Perozo E.
Nat Struct Mol Biol. 2006 Apr;13(4):319-22. Epub 2006 Mar 12.

Electrostatic interaction of a K+ channel RCK domain with charged membrane surfaces.
Ptak CP, Cuello LG, Perozo E.
Biochemistry. 2005 Jan 11;44(1):62-71.

Molecular architecture of the KvAP voltage-dependent K+ channel in a lipid bilayer.
Cuello LG, Cortes DM, Perozo E.
Science. 2004 Oct 15;306(5695):491-5.

EPR approaches to ion channel structure and function.
Perozo E, Cuello LG, Cortes DM, Liu YS, Sompornpisut P.
Novartis Found Symp. 2002;245:146-58; discussion 158-64, 165-8. Review.

Molecular architecture of full-length KcsA: role of cytoplasmic domains in ion permeation and activation gating.
Cortes DM, Cuello LG, Perozo E.
J Gen Physiol. 2001 Feb;117(2):165-80.

Structural rearrangements underlying K+-channel activation gating.
Perozo E, Cortes DM, Cuello LG.
Science. 1999 Jul 2;285(5424):73-8.

Three-dimensional architecture and gating mechanism of a K+ channel studied by EPR spectroscopy.
Perozo E, Cortes DM, Cuello LG.
Nat Struct Biol. 1998 Jun;5(6):459-69.

pH-dependent gating in the Streptomyces lividans K+ channel.
Cuello LG, Romero JG, Cortes DM, Perozo E.
Biochemistry. 1998 Mar 10;37(10):3229-36

Luis G. Cuello Laboratory

Center for Membrane Protein Research