Luis G. Cuello Laboratory

Center for Membrane Protein Research

TTUHSC   

Education: 

- PhD in Molecular Physiology and Biological Physics. University of Virginia. 2005

- MS in Molecular Physiology and Biological Physics. University of Virginia. 2000

Licenciate in Biology, Facultad de Ceincias, Universidad Central de venezuela. 1993

Award and Honors:

-Awarded with a Pre-doctoral fellowship from American Heart Association 2001-2003. “Three dimensional-architecture of a putative voltage activated potassium channel by EPR spectroscopy”. Mid-Atlantic Affiliate Research Committee.

-Special Award for the Michael J. Peach Outstanding Graduate Student Award year 2003. University of Virginia. Physiology Department.

-Nomination for the Michael J. Peach Outstanding Graduate Student Award year 2000. University of Virginia. Physiology Department.

-Ann O’Brien Leone Outstanding Research Scholarship Award 2000. University of Virginia, University of Virginia Fund.

Publications: 

- Chakrapani, S, Cuello, L.G., Cortes, D.M., Perozo, E. StructuralDynamics of an isolated-Voltage Sensor Domain in Lipid Bilayers. Structure. 2008 Mar 11;16(3):398-409.

- Blunck, R., Cordero, J., Cuello, L.G., Perozo, E. and Bezanilla F.  Detection of the Opening of the Bundle Crossing in KcsA with Fluorescence Lifetime Spectroscopy reveals the Existence of two Gates for Ion Conduction. Journal of General Physiology. 2006 Nov;128(5):569-81.

- Cordero, J; Cuello, L.G.; Zhao, Y; Jogini V, Chakrapani, S; Roux, B and Perozo, E. Molecular Determinants of Gating at the Potassium Channel Selectivity Filter. Nature Structural and Molecular Biology. Mar 12 2006.

- Cordero J, Cuello LG, Perozo E. Voltage-dependent gating at the KcsA selectivity filter. Nature Structural and Molecular Biology. Mar 12 2006.

- Ptak CP, Cuello LG, Perozo E. Electrostatic interaction of a K+ channel RCK domain with charged membrane surfaces. Biochemistry. 2005 Jan 11;44 (1):62-71.

- Cuello LG, Cortes DM, Perozo E. Molecular architecture of the KvAP voltage-dependent K+ channel in a lipid bilayer. Science. 2004 Oct 15;306 (5695):491-5. 

- Cortes, D.M., Cuello, L.G. and Perozo, E. Molecular Architecture of Full-Length KcsA Derived from Site-Directed Spin-Labeling. Journal General Physiology 2001. 117: 165-180.

- Perozo, E., Cortes, D.M. and Cuello, L.G. Structural Rearrangements Underlying K+ Channel Activation Gating. Science 1999. 285: 73-78.

- Perozo, E., Cortes, D.M. and Cuello, L.G. Three-dimensional architecture and gating mechanism of a K+ channel studied by EPR spectroscopy. Nature Structure Biology 1998. 5:459-469.

- Cuello, L.G., Romero, J.G., Cortes, D.M., Perozo, E. pH-dependent gating in the Streptomyces lividans K+ Channel. Biochemistry 1998. 37: 3229-3236.

Cuello, L.G., Quiñones, M.E., Finol, H.J. et al. Neuromuscular Junction Alterations in-patients with AIDS. Acta Microscopica 1994. 3:73-77.


Book Chapter:


- Perozo, E., Cuello, L.G., Cortes, D.M., Liu, Y-S and Sompornpisut, P. (2002). EPR approaches to ion channel structure and function. In “Ion channels: from atomic resolution physiology to functional genomics”. Novartis Foundation Symposium. John Wiley & Cons LTD; UK
Luis G. Cuello PhD
Associate Professor
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